Open AccessIntratumoral spatial heterogeneity of BTK kinomic activity dictates distinct therapeutic response within a single glioblastoma tumor
Author(s) -
Ahmed N. Ibrahim,
Daisuke Yamashita,
Joshua C. Anderson,
Moaaz Abdelrashid,
Amr Alwakeal,
Dagoberto Estévez-Ordoñez,
Svetlana V. Komarova,
James M. Markert,
Violaine Goidts,
Christopher D. Willey,
Ichiro Nakano
Publication year - 2020
Publication title -
journal of neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.564
H-Index - 210
eISSN - 1933-0693
pISSN - 0022-3085
DOI - 10.3171/2019.7.jns191376
Subject(s) - bruton's tyrosine kinase , small hairpin rna , cancer research , gene knockdown , tyrosine kinase , medicine , glioblastoma , transcriptome , biology , computational biology , signal transduction , gene , genetics , gene expression
Despite significant recent efforts applied toward the development of efficacious therapies for glioblastoma (GBM) through exploration of GBM's genome and transcriptome, curative therapeutic strategies remain highly elusive. As such, novel and effective therapeutics are urgently required. In this study, the authors sought to explore the kinomic landscape of GBM from a previously underutilized approach (i.e., spatial heterogeneity), followed by validation of Bruton's tyrosine kinase (BTK) targeting according to this stepwise kinomic-based novel approach.