Open AccessIs the Importance of Magnesium in Chronic Kidney Disease Underappreciated?
Author(s) -
Delia Timofte,
Andra-Elena BalcangiuStroescu,
Dorin Dragoș,
Mihaela Tănăsescu,
Iuliana GHENU,
Ileana Adela Văcăroiu,
Adrian Tulin,
Adina Măndiţă,
Ovidiu Știru,
Mihai Dumitru,
Anca Macovei Oprescu,
Iulian Slavu,
Dorin Ionescu,
Cornelia Nițipir
Publication year - 2021
Publication title -
modern medicine
Language(s) - English
Resource type - Journals
eISSN - 2360-2473
pISSN - 1223-0472
DOI - 10.31689/rmm.2021.28.2.139
Subject(s) - medicine , kidney disease , left ventricular hypertrophy , endocrinology , hyperparathyroidism , kidney , disease , vascular disease , secretion , cardiology , blood pressure
Magnesium (Mg) is one of the most important cations in the organism, essential for regulating vascular tone, cardiac rhythm, and endothelial functions. In patients with advanced stage chronic kidney disease (CKD) Mg deficit was associated in various studies with vascular calcifications and increased cardiovascular morbidity and mortality. Patients with CKD frequently have hyperparathyroidism, parathormone (PTH) being an important risk factor for vascular calcifications. Increased serum Mg levels inhibit PTH secretion and stimulate left ventricular hypertrophy, while low serum Mg levels stimulate PTH secretion. Correcting Mg de deficiency results in reduced cardiovascular mortality in these patients.