Open AccessEFFECT OF PHYSICAL EXERCISE ON COLORECTAL CANCER: SYSTEMATIC REVIEW
Author(s) -
Marcelo Barbosa Neves,
Alessandra de Figueiredo Gonçalves,
Giovanni Alves,
Luiz Carlos Takita,
Letícia Silva Fagundes,
Ana Keren dos Santos Rocha,
Udenilson Nunes da Silva,
Julia Fogaça Toniello,
Rondon Tosta Ramalho
Publication year - 2021
Language(s) - English
Resource type - Journals
ISSN - 2411-2933
DOI - 10.31686/ijier.vol9.iss2.2930
Subject(s) - colorectal cancer , medline , scielo , medicine , aerobic exercise , resistance training , physical activity , inflammation , cancer , physical therapy , bioinformatics , biology , biochemistry
Aerobic and resistance physical exercise can activate different molecular pathways due to different intensities, duration, and mechanical loads imposed on the muscles. The activity can result in metabolic adaptations, such as increased mitochondrial mass, oxygen supply, glucose uptake, and antioxidant capacity. The method of this systematic review followed recommendations proposed by the PRISMA Statement. Were included studies that used physical exercise as an intervention in rats and mice with induced colorectal cancer. The Studies' selection was on databases: Bireme, PubMed, Science Direct, Medline, Ibecs, Lilacs, Bdenf, Binacis, Scielo, and bibliographic references selected articles. Animal models researches showed that aerobic and resistance exercise could reduce several risk factors like oxidating stress and the tumor's pro-inflammatory status. That happens due to cytokines' regulation, thereby improve organic's defenses and reduce colon inflammation.