Open AccessMeta-analysis: hydroxychloroquine therapy approach with or without azithromycin against covid-19
Author(s) -
Josilene Nascimento do Lago,
Cosmo de Sousa Costa,
Larissa Emily de Carvalho Moraes,
Raissa Ribeiro da Silva,
Gleiciane Moraes Gonçalves,
Thainar Stefanie Barbosa de Oliveira,
Tatiane Roseli Alves Castro,
Thalles Ricardo Melo de Souza,
Christian Pacheco de Almeida,
Lorena Victória de Souza Ferreira,
Alex Jean Ferreira da Silva,
Widson Davi Vaz de Matos,
Renan Rocha Granato,
Ademir Ferreira da Silva Júnior
Publication year - 2020
Language(s) - English
DOI - 10.31686/ijier.vol8.iss8.2493
Subject(s) - hydroxychloroquine , azithromycin , medicine , covid-19 , medline , randomized controlled trial , clinical trial , meta analysis , intensive care medicine , antibiotics , disease , political science , law , infectious disease (medical specialty) , microbiology and biotechnology , biology
Objective: identify and analyse the evidences about the use of hydroxychloroquine with or without azithromycin in covid-19. Methods: This is a systematic review with meta-analysis using posted articles in December 2019 until May 2020. The research was formulated by a question structured using PICO strategy, in these data bases: BVS, PUBMED, MEDLINE, LILACS, BDENF e SCIELO. Results and discussion: Resulted in 9 articles founded by the PRISMA, approaching 4182 patients. PICO strategy selected and analysed 5 articles projected in Forest plots. Resulting in tree clinical trials (RR: 1.15; IC95%, 0.76 a 1.73), which did not found big differences in the outcome in the groups of patients who used HCQ with or without AZT, comparing with the control group. Two studies analysed the number of deaths/intubations in comparative group, experimental group and control (RR:1.86; IC: 95%, 1.54 a 2.26) resulting in more chance of death /intubation in patients who used HCQ. Conclusion: It was found that is not possible to prove the efficacy of these drugs, due to the limited number of randomized and controlled clinical trials. Therefore, the encourage of scientific production about the HCQ and AZT against Covid-19 is more than necessary.