Open AccessBasal cell carcinoma - epidemiology, pathogenesis, pathology, and association with inflammation biomarkers. A review
Author(s) -
Rondon Tosta Ramalho,
Luiz Carlos Takita,
César Augusto Sobrinho,
Marcel Arakaki Asato,
Gabriely Lessa Sacht,
Günter Hans Filho,
Rondon Tosta Ramalho,
Ricardo Dutrra Aydos
Publication year - 2020
Language(s) - English
DOI - 10.31686/ijier.vol8.iss3.2226
Subject(s) - basal cell carcinoma , carcinogenesis , biology , cancer research , pathogenesis , dna damage , cytotoxic t cell , pathology , inflammation , basal (medicine) , cell , immunology , gene , basal cell , genetics , dna , medicine , endocrinology , in vitro , insulin
Basal cell carcinoma is the most common malignant neoplasm in humans, with low mortality, high morbidity, and exposure to solar radiation (UVB and UVA) is the most critical risk factor. Ultraviolet B rays generate mutagenic photoproducts in DNA and mutations in important genes regulating cellular functions, such as the tumor suppressor gene TP53. Ultraviolet A rays generate cytotoxic and mutagenic free radicals, potentiating the effects of UVB rays.. There is current evidence to support the role of inflammatory biomarkers related to tumorigenesis of basal cell carcinoma.