Open AccessMURINE EXPERIMENTAL MODELS IN CARCINOGENESIS STUDIES ARE EFFICIENT?
Author(s) -
Eliza Miranda Ramos,
Antônio Carlos de Abreu,
Evair Moisés de Lima Santiago,
Gislaine Recaldes de Abreu,
Marcelo Barbosa Neves,
Rondon Tosta Ramalho
Publication year - 2020
Language(s) - English
DOI - 10.31686/ijier.vol8.iss1.2153
Subject(s) - prostate cancer , cancer , context (archaeology) , disease , carcinogenesis , public health , cancer prevention , cancer incidence , medicine , human health , biology , environmental health , pathology , paleontology
Economic and social development has essential repercussions on the health of populations, as it alters the morbidity and mortality profile and favors the increase in exposures and risks to human health, especially the risk of cancer. Cancer is considered a significant public health problem worldwide, and remains with high incidence rates, being considered a complex disease, with multifactorial causes. The permanent incidence rates of prostate cancer prove to be one of the most prevalent, considered the second most common cancer in men worldwide, and a leading cause of deaths from chronic noncommunicable diseases. Among the different types of cancer, prostate cancer has been the subject of great scientific interest. In this context, animal models are valuable for studying cancer-related aspects, the use of animal models has the potential to increase our understanding of carcinogenesis, tumor biology, and the impact of specific molecular events on tumor biology. Animal models with specific human cancer characteristics can be used to test cancer prevention and treatment strategies. In this review, we aim to show how the use of animal models as an essential tool in the study of the molecular mechanisms of carcinogenesis.