Open AccessANALYSIS OF ANTIMICROBIAL, ANTIBIOFILM, AND HEALING ACTIVITY OF LIPID NANOCARRIERS BASED ON TUCUMAN BUTTER (Astrocaryum vulgare), FIXED OILS FROM MICROALGAE Chlorella homosphaera AND FROM UVA SEED Vitis vinifera
Author(s) -
Larissa da Silva Silveira,
Aline Rossato,
Pâmella Scharamm Oliveira,
Elisandra Da Silva Pena Da Fonseca,
Luísa Donato Bortoluzzi,
Wanessa De Carvalho Vieira,
Guilherme Chagas Kurtz,
Walter Paixão de Souza Filho,
Diego de Souza,
Liana da Silva Fernandes,
Michele Rorato Sagrillo
Publication year - 2022
Language(s) - English
Resource type - Journals
ISSN - 2411-2933
DOI - 10.31686/ijier.vol10.iss2.3630
Subject(s) - antimicrobial , nanocarriers , biology , food science , context (archaeology) , microbiology and biotechnology , essential oil , traditional medicine , pharmacology , medicine , paleontology , drug
Therapeutic alternatives of natural origin have been arousing the interest of large research centers that are looking for new bioactive molecules to treat numerous diseases in the context of public health. Among them, infectious diseases, which present antimicrobial resistance, deserve attention. The present study aimed to evaluate the antimicrobial activity of lipid nanocarriers (CLN), as well as the healing activity, arising from the association of tucumã butter with grape seed oil and another one containing microalgae oil. Two formulations were prepared using the high-speed homogenization technique, which was evaluated for antimicrobial action for 10 strains of great clinical importance, including a multiresistant and healing activity. The formulation with Chlorella homosphaera oil showed growth inhibition for the 10 strains tested, in addition to antibiofilm activity for 8 strains, bactericidal action for 3 of 3 isolates, and satisfactory healing action in 48 hours.