Open AccessDynamics of blood morphological indicators of Wistar line rats under parenteral BLV infection
Author(s) -
А.В. Красников,
A. S. Belyakova,
Е. С. Красникова
Publication year - 2021
Publication title -
innovacii i prodovolʹstvennaâ bezopasnostʹ
Language(s) - English
Resource type - Journals
ISSN - 2311-0651
DOI - 10.31677/2311-0651-2020-28-2-53-58
Subject(s) - aplastic anemia , neutropenia , enzootic , leukemia , immunology , biology , intraperitoneal injection , medicine , physiology , endocrinology , bone marrow , toxicity , virus
Hematological studies of Wistar rats with intraperitoneal infection of their lymphocytes from BLV-infected cows revealed markers characteristic of the leukemic process induced by the pathogen enzootic leukemia in cattle. In 75% of experimental animals, lymphocytic leukemia and neutropenia were detected. The number of lymphocytes in the blood of rats of the experimental group was 17-36 % more than in the control group, leukocytes in average by 30 %. The animals of the experimental group showed signs of erythrocyte aplasia, hemolytic or aplastic anemia. Allergy markers were observed in individual rats. This allows us to recommend an intraperitoneal method of infecting laboratory rats with suspended lymphocytes from infected livestock for rapid and informative reproduction of experimental BLV infection.