Open AccessBLOOD BIOCHEMICAL PARAMETERS OF RATS – WISTAR LINE UNDER THE BLV EXPERIMENTAL INFECTION
Author(s) -
Е. С. Красникова,
А.В. Красников,
Р. В. Радионов,
D. A. Artemev,
В. И. Околелов
Publication year - 2020
Publication title -
innovacii i prodovolʹstvennaâ bezopasnostʹ
Language(s) - English
Resource type - Journals
ISSN - 2311-0651
DOI - 10.31677/2311-0651-2019-24-2-69-75
Subject(s) - spleen , leukemia , bovine leukemia virus , offspring , fibrosarcoma , hyperplasia , kidney , endocrine system , pathology , biology , medicine , immunology , endocrinology , virus , pregnancy , hormone , genetics
It is founded that аn outbred Wistar line rats are susceptible to oral infection with bovine leukemia virus. Pathognomonic for leukemia changes such as neoplastic processes, as well as hyperplasia, adenocarcinoma, mastocytoma and fibrosarcoma in spleen were revealed in rats, when feeding them milk of BLV-infected and affected with leukemia cows. Progressive signs of intoxication, endocrine disorders and development of malignant processes were revealed by biochemical studies of the rats’ blood serum, regardless of whether the milk of infected or affected with leukemia cows was fed to them. In the offspring of experimental animals pronounced signs of liver, kidney and myocardium damages were observed.