Open AccessHEMATOLOGICAL PARAMETERS OF RATS - WISTAR LINE UNDER THE BLV EXPERIMENTAL INFECTION
Author(s) -
Е. С. Красникова,
А.В. Красников,
Р. В. Радионов,
A. S. Belyakova,
В. И. Околелов
Publication year - 2018
Publication title -
innovacii i prodovolʹstvennaâ bezopasnostʹ
Language(s) - English
Resource type - Journals
ISSN - 2311-0651
DOI - 10.31677/2311-0651-2018-0-4-138-145
Subject(s) - offspring , immunology , transplacental , leukemia , pathogenesis , platelet , immunity , medicine , thrombocytosis , pregnancy , biology , physiology , fetus , immune system , placenta , genetics
Rats Wistar line were found to be a good laboratory model for the BLV infection pathogenesis studying. At the initial stage of infection, the rats’ first generation offspring were born healthy and colostral immunity protected them from infection for at least a month. Transplacental transmission of the virus to the rats’ second generation offspring was established in 30-33 % of experimental animals. The results of hematological studies have shown that in animals of experimental groups, thrombocytosis progressed over time and the average volume of platelets increased, which may be evidence of the megakaryocytic leukemia development. In some cases, there were signs of allergy, hemolytic anemia, lymphocytic leukemia. The most significant changes were found in the offspring of experimental rats.