DEVELOPMENT OF AN INFLAMMATORY RESPONSE IN LABORATORY ANIMALS AT EXPERIMENTAL MYCOTIC INFECTION AND IMMOBILIZATION STRESS

The data on the methods of modeling polyetiological stress in laboratory mice and its effect on the development of the inflammatory response and the nature of pathological and anatomical changes are presented. At the first stage, two groups of animals simulated polyetiological stress. For this, the animals were infected with micromycete intraperitoneally and left stationary for several hours a day. After that, infection was assessed by detecting micromycete in the peripheral blood of animals. At the second stage, the degree of occurrence and the nature of pathological and anatomical changes were studied with different methods of micromycete administration. It was noted that as a result of the simultaneous exposure to two stress factors, micromycetes in the peripheral blood were detected on the 8th day of the study. At the same time, the influence of one stress factor led to the generalization of the process only on the 17th day. With different methods of infection in laboratory mice, characteristic changes were revealed in the internal organs, which in all groups of animals were represented mainly as single and multiple abscesses of different localization, as well as fistulas in the left caudal part of the peritoneum. Abscesses in the region of the left forearm were filled with characteristic purulent contents: a curdled mass of light gray with an unpleasant odor or odorless. These pathological and anatomical changes were noted in 90% of the animals of their total number in the experiment. The introduction of R. syclopium followed by the exposure of white mice to IMO stress leads to 100% death of animals on days 1-2 from the onset of stress. Animals that were only injected with P. cyclopium remained alive until the end of the study.