Open AccessIMPACT OF ULTIMATELY LOW CONCENTRATIONS OF MEDICINES ON THE OPSONOCYTOPHAGIC RESPONSE OF NEUTROPHILS
Author(s) -
М. В. Лазарева,
Н. А. Шкиль
Publication year - 2019
Publication title -
vestnik novosibirskogo gosudarstvennogo agrarnogo universiteta
Language(s) - English
Resource type - Journals
ISSN - 2072-6724
DOI - 10.31677/2072-6724-2019-50-1-126-132
Subject(s) - phagocytosis , chemistry , in vitro , biology , immunology , microbiology and biotechnology , biochemistry
The paper shows the impact of ultra-low concentrations of medical specimens on neutrophil opsonocytophagic reaction (ORR) parameters, such as phagocytic activity of neutrophils (PA), phagocytic number (PN), phagocytic index (PI), in vitro. The researchers observed the highest phagocytic activity in the control group 3 (placebo-control) in Creosotum C30 and, Ovarinine (P<0.01). When exploring the qualitative parameters of neutrophil opsonophagocytic reaction – phagocytic number – the authors observed the highest index in Ovarinine (26.79±5.13 m.t.), Secale cornutum C6 (16.57±0.46 m.t.) and Thuja D3 (15.58±1.30 m.t.). When estimating the phagocytic index in opsonophagocytic reaction, the inhibitory effect of saline solution (1.64±0.07 m.t.) was observed in relation to the placebo-control group No. 3 (2.42±0.21 m.t.) on 32.23%. The regularities revealed show that the lowest indexes of cellular immunity (FA, FF, FI) are established in Platinum C6; FF and FI - in Lilium tigrinum C12. The highest parameters of opsonocytophagic reaction were observed in the complex specimen Ovarinine, which includes Apis mellifelica C12, Pulsatilla pratensis C30, Sulfur C200, Sepia C6, Creazotum C30, Lachesis C12. Ovarinine is characterized by 9.65% increase in phagocytic activity, 997.95% in phagocytic number and 1106.76% in phagocytic index in comparison with the control group 1 with lactose.