Open AccessUnderlying Disorders, Clinical Phenotypes, and Treatment Diversity among Patients with Disseminated Intravascular Coagulation
Author(s) -
Hiroyuki Ohbe,
Kazuma Yamakawa,
Kohei Taniguchi,
Kojiro Morita,
Hiroki Matsui,
Kiyohide Fushimi,
Hideo Yasunaga
Publication year - 2020
Publication title -
jma journal
Language(s) - English
Resource type - Journals
eISSN - 2433-3298
pISSN - 2433-328X
DOI - 10.31662/jmaj.2020-0023
Subject(s) - medicine , disseminated intravascular coagulation , sepsis , cancer , pancreatitis , coagulation disorder , organ dysfunction , intensive care medicine , coagulation
Clinical guidelines state that disseminated intravascular coagulation (DIC) treatment should be based on three clinical phenotypes: the marked bleeding type (e.g. leukemia, trauma, obstetric diseases, or aortic diseases); organ failure type (sepsis or pancreatitis); and asymptomatic type of DIC (solid cancer). However, among the various underlying disorders of DIC, the clinical presentations of bleeding or organ failure have not to date been well documented. The present study aimed to evaluate whether underlying disorders of DIC would affect clinical outcome including death, organ failure, and bleeding.