Open AccessSOME FEATURES OF THE RELATIONSHIP BETWEEN PATHOGENETIC MECHANISMS OF HYPOSALIVATION IN RHEUMATOID ARTHRITIS AND SJOGREN'S SYNDROME
Author(s) -
D. O. Yakimenko
Publication year - 2018
Publication title -
lìkarsʹka sprava/lìkarsʹka sprava
Language(s) - English
Resource type - Journals
eISSN - 2706-8803
pISSN - 1019-5297
DOI - 10.31640/jvd.7-8.2018(13
Subject(s) - medicine , rheumatoid arthritis , rheumatoid factor , autoantibody , anti nuclear antibody , dry mouth , gastroenterology , oral cavity , arthritis , antibody , immunology , dentistry , saliva
Oral cavity damage, impaired salivation, the presence of autoantibodies and the level of inflammatory markers were studied in 150 patients with rheumatoid arthritis – RA (27 males and 123 females), mean age – (50.10 ± 0.44 years); 90 patients without complaints of dry mouth, 31 patients with complaints of dry mouth and 29 patients with Sjogren's syndrome. It was found that all patients with RA (without complaints of dry mouth and with them) had a decrease in salivation (0.29 ml/min ± 0.07 ml/min and 0.25 ml/min ± 0.05 ml/min) , which is associated with an increase in the activity of the inflammatory process and the presence of autoantibodies. Shegren's syndrome in RA was detected in 19% of patients, it is associated with significant deterioration of oral hygiene, expressed by hyposalivation (0.14 ml/min ± 0.06 ml/min), high activity of the inflammatory process, a wide spectrum of autoantibodies (rheumatoid factor, antinuclear antibodies in low titres, antibodies Ro and La), an increase in the content of C-reactive protein and interleukin-1.