Open AccessPathogenetic role of vitamin D deficiency and immune-inflammatory disorders in development of fetal distress in pregnant women with chronic hydramnion
Author(s) -
N. A. Gaistruk,
L.G. Dubas,
A. N. Gaistruk,
А. В. Мельник,
O. L. Liovkina
Publication year - 2020
Publication title -
lìkarsʹka sprava/lìkarsʹka sprava
Language(s) - English
Resource type - Journals
eISSN - 2706-8803
pISSN - 1019-5297
DOI - 10.31640/jvd.3-4.2020(3
Subject(s) - polyhydramnios , medicine , immune system , pregnancy , fetus , vitamin d and neurology , vitamin d deficiency , fetal distress , endocrinology , physiology , immunology , obstetrics , biology , genetics
The role of vitamin D deficiency and immune-inflammatory disorders in the mechanisms of development of fetal distress in pregnant women with chronic polyhydramnios remains unexplored. Objective: to evaluate the role of vitamin D deficiency and associated immune inflammatory disorders in the development of fetal distress in pregnant women with chronic polyhydramnios. Materials and methods. Surveyed 30 women with a physiological course of pregnancy and 90 pregnant women with chronic polyhydramnios. In the serum, the level of the metabolite of vitamin D – 25(OH)D and the cytokines IL-10 and IL-6 were determined by enzyme immunoassay using standard kits. Statistical processing of the obtained results was performed using standard methods using the «MS Excel» and «Statistica SPSS 10.0 for Windows» application package. The results of the research. In pregnant women with chronic polyhydramnios, there is a significant decrease of the metabolite of vitamin D – 25(OH)D level by 21 % in the serum, a decrease of the level of the anti-inflammatory cytokine IL-10 by 26.4 % and an increase of the concentration of pro-inflammatory IL-6 by 17 % compared to women with physiological course of pregnancy. The occurrence of fetal distress against the background of chronic polyhydramnios is accompanied by a intensification of vitamin D deficiency and immune-inflammatory disorders: levels 25(OH)D and IL-10, respectively, by 18.5 % and 17.5 % less, and IL-6 by 13.3 %, than in women with chronic polyhydramnios without fetal distress. The expressiveness of immune disorders in the organism of pregnant women with chronic polyhydramnios is determined by the level of vitamin D in the organism. Thus, in women with a deficiency of 25(OH)D in the serum, a significant decrease in the IL-10 concentration by 47.8 % and a significant increase in the IL-6 level by 34.6 % were recorded in comparison with the indicators in women with vitamin D deficiency. Conclusions. Vitamin D deficiency and associated immune-inflammatory disorders play an important role in the development of fetal distress in pregnant women with chronic polyhydramnios.