Open AccessEvaluation of laboratory research data in patients with multiple sclerosis in the aspect of comboridity
Author(s) -
G. Chupryna
Publication year - 2019
Publication title -
lìkarsʹka sprava/lìkarsʹka sprava
Language(s) - English
Resource type - Journals
eISSN - 2706-8803
pISSN - 1019-5297
DOI - 10.31640/jvd.1-2.2019(11
Subject(s) - multiple sclerosis , medicine , concomitant , cerebrospinal fluid , autoantibody , urine , creatinine , antigen , gastroenterology , immunology , antibody
The objective of the work – to study laboratory data in patients with multiple sclerosis in order to clarify the nature of the influence of comorbid pathology on the level of dysfunction of biochemical processes of the body. We examined 216 patients with multiple sclerosis with various forms of course. Patients of the general sample were divided into two groups: І (n = 109) – without concomitant diseases and ІІ (n = 107) – with the presence of concomitant diseases. The results of general clinical tests of blood and urine, a biochemical blood test, a study of cerebrospinal fluid, the immune status of the blood, and the level of autoantibodies to brain antigens were evaluated. General clinical blood and urine tests, a biochemical blood test were performed on all 216 patients with multiple sclerosis from the study group. The study of cerebrospinal fluid (macroscopic, microscopic, polymerase chain reaction) and immunological blood tests (study of indicators of cellular and humoral immunity, the level of autoantibodies to brain antigens) were performed in 42 patients with multiple sclerosis of both groups. As a result, it was found that significant differences between groups І and ІІ exist due to an increase in platelet counts in patients of group ІІ (P < 0.05) and AsAT concentration (P < 0.05), an increase in creatinine concentration (P < 0.05), an increase in blood cholesterol (P < 0.05). Such differences in the indicators of general clinical and biochemical blood tests are, in our opinion, due to the presence of cardiovascular and gastroenterological comorbidity in patients with multiple sclerosis and correlate with a decrease in their overall well-being. As a result of studying the general analysis of urine in 84.7 % of patients of the general sample, there were general inflammatory signs, which were more pronounced in several indicators in the ІІ group of patients, clinically correlated with the severity of pelvic disorders. Systemic and deeper changes in the level of NK cells, the main protein of myelin, the total human brain antigen, as well as the immunoregulatory cycle in patients with multiple sclerosis with comorbid pathology were also established.