Open AccessBasis of the general theory of pathology (Part 2. Pathogenesis of chronic diseases)
Author(s) -
V. S. Prokopchook,
A. V. Lyckbäck
Publication year - 2018
Publication title -
lìkarsʹka sprava/lìkarsʹka sprava
Language(s) - English
Resource type - Journals
eISSN - 2706-8803
pISSN - 1019-5297
DOI - 10.31640/jvd.1-2.2018(01
Subject(s) - mechanism (biology) , etiology , disease , pathogenesis , medicine , function (biology) , chronic disease , intensive care medicine , bioinformatics , neuroscience , pathology , psychology , biology , epistemology , evolutionary biology , philosophy
The authors believe that, despite of the endless variety of pathology, there is a single stereotyped pathogenetic mechanism for all chronic diseases. This mechanism doesn't dependent on a cause of an illness. If unnumbered etiological factors have a direct link to a damage of a certain number of cells (structures) of the target organ, then a disease, as a reaction to this damage, aims to restore the structure and function of the damaged organ. However a new pathogenetic mechanism arises in the course of a disease. This mechanism is based on energy deficiency. It arises due to violations of biorhythms of a remaining tissue. The violations of biorhythms in their turn are based on deviations from the law of «optimal construction». This mechanism destroys the remaining tissue that haven't been damaged by etiological factors. A "separation" of a disease from an etiologic factor occurs. A disease continues its course even without external damaging factors. Consequently a treatment of chronic diseases requires a fundamentally different approach than etiotropic therapy. Until now only an empirically obtained experience of non-specific treatment has been used. Therefore all existing therapy requires a fundamental revision.