Open AccessAssessment of the Effect of Multidrug Resistance Clostridium difficile Clinical Strains on the Dynamics of Clostridium difficile Infection Rate at Pediatric Oncological Hospital
Author(s) -
М. Г. Швыдкая,
А. М. Затевалов,
Д. Т. Джандарова,
С. Д. Митрохин,
O.E. Orlova
Publication year - 2021
Publication title -
èpidemiologiâ i vakcinoprofilaktika
Language(s) - English
Resource type - Journals
eISSN - 2619-0494
pISSN - 2073-3046
DOI - 10.31631/2073-3046-2021-20-1-26-31
Subject(s) - clostridium difficile , metronidazole , clindamycin , tigecycline , medicine , microbiology and biotechnology , multiple drug resistance , clostridium , vancomycin , antibiotics , biology , bacteria , staphylococcus aureus , genetics
Relevance. Atthechildren'soncologicalhospitalguidelinestotreatpatientswithseveralgroupsofantibioticsatthesametime,whichensurestheformationofmulti-resistantstrainsofClostridiumdifficile,whichhavea selective advantage for the Clostridium difficile infection developing, and also cause epidemics and /or in associating with an increase in the severity of Clostridium difficile – infection.Aims. MultidrugresistanceClostridiumdifficilestrainsandClostridiumdifficileinfectionrateatpediatriconcologicalhospital.Results. AninvestigationoftheClostridiumdifficileresistancestrainscarriedoutamongchildrenatthechildren'soncologicalhospital.143 toxigenic strainsareresistantto moxifloxacin 72.41%, clindamycin 63.72%,rifampicin35.54%,tetracycline26.45%, tigecycline11.42%,vancomycin4.4%,metronidazole3.9%.Atthesametime,theincreasemultidrug-resistantstrainsproportionnoteatthelevel of 3–4% per year. However, the rate of Clostridium difficile infection among children at the oncological hospital remained at the level of 0.4% to 3.1% with a downward trend. As a result, statistical calculations showed the absence of correlation between multidrug resistance and morbidity.Conclusions. Detection of multidrug-resistant microorganisms among toxigenic Clostridium difficile strains proves the need for further study of this problem in Russia and the advisability of monitoring Clostridium difficile infection rate and multidrug resistance Clostridium difficile strains at pediatric oncological hospitals.