Open AccessFormation Features of the Natural and Post-Vaccination Anti-Diphtheria Antitoxic Immunity
Author(s) -
Е. А. Шмелёва,
Т. Н. Попова,
Alexandra Safronova
Publication year - 2021
Publication title -
èpidemiologiâ i vakcinoprofilaktika
Language(s) - English
Resource type - Journals
eISSN - 2619-0494
pISSN - 2073-3046
DOI - 10.31631/2073-3046-2021-20-1-100-113
Subject(s) - diphtheria , vaccination , immunity , population , booster (rocketry) , immunology , medicine , booster dose , immune system , immunization , environmental health , physics , astronomy
Relevance. Againstthebackgroundofepidemiologicalwell-beingfordiphtheriainfection,theformationoftheoptimalstructureofthepopulationpost-vaccinationantitoxicimmunityremainsanurgentproblem.Aims. Thereviewisdevotedtoanti-toxicantidiphtheriaimmunityandthepossibilitytoformtheoptimalstructureofpost-vaccinationanti-toxicpopulationimmunityusingthesmallboosterdosesofanatoxin.Results. Specialattentionispaidtotheformationofantitoxicpopulationimmunityina natural way during the pre-vaccination period. It is proposed to pay attention to the immunosuppressive characteristics of anatoxin and the immune response to booster its small doses. Natural decrease in the concentration indicators of post-vaccination antitoxic IgG in the blood of adults has been demonstrated. A mathematical analysis of determining the structure of post-vaccination population immunity in all age groups of the population is proposed.Conclusions. The small booster personalized doses of anatoxin in adolescents and adults will contribute to the creation of optimal population anti-diphtheria protection of these age groups of the population.