Open AccessComparative Characteristics of Inactivation Agents for HFRS Vaccine Development
Author(s) -
С. С. Курашова,
А. А. Ишмухаметов,
М.А. Егорова,
М. В. Баловнева,
Tamara K. Dzagurova,
Е. А. Ткаченко
Publication year - 2018
Publication title -
èpidemiologiâ i vakcinoprofilaktika
Language(s) - English
Resource type - Journals
eISSN - 2619-0494
pISSN - 2073-3046
DOI - 10.31631/2073-3046-2018-17-4-26-29
Subject(s) - immunogenicity , virology , virus , formaldehyde , biology , chemistry , microbiology and biotechnology , antibody , immunology , biochemistry
The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.