Open AccessEstimation of Prophylactic Efficacy of the Grippol® Vaccine for Large-Scale Immunization in Adult and Children's Organized Collectives in the Republic of Belarus
Author(s) -
Н. П. Шмелева,
В. П. Шиманович,
Н. В. Сивец,
Т. П. Лапо,
Наталия Васильевна Грибкова
Publication year - 2017
Publication title -
èpidemiologiâ i vakcinoprofilaktika
Language(s) - English
Resource type - Journals
eISSN - 2619-0494
pISSN - 2073-3046
DOI - 10.31631/2073-3046-2017-16-5-33-42
Subject(s) - medicine , immunization , pediatrics , cohort , vaccine efficacy , vaccination , estimation , influenza vaccine , immunology , antibody , management , economics
Abstract estimation of anti-epidemic efficacy of a polymer-subunit vaccine Grippol® for large-scale immunization in adult work collectives and secondary schools in Vitebsk, Minsk and Grodno was conducted. Acute respiratory infection agents were detected by the means of RT-PCR in selected individuals. The overall number of participants was 12308 (5391 were children aged 6 - 17 and 6917 were 18 years or older). Influenza and ARI morbidity analysis demonstrates that Grippol® plus has a high anti-epidemic efficacy, reducing the influenza morbidity in the vaccinated cohort by 2.1 (adults) and 3.0 (children) times compared to that in unvaccinated persons. Efficacy and efficacy rate amounted to 50 3% and 2 2 in adults and 66 2% and 3 0 in children respectively A decrease in number of recurrent diseases complications in children was also demonstrated A dynamic morbidity analysis showed that in unvaccinated children there had been an evident increase in influenza and ARI among the unvaccinated children in late January - February 2016, while among the children who were vaccinated the morbidity rate was consistently low across all months of the influenza season.