Open AccessExperimental Study of Immunological Activity of Live Plague Vaccine Subjected to Extreme Temperature
Author(s) -
Д. А. Будыка,
А. А. Фисун,
Е. Л. Ракитина,
Н. В. Абзаева
Publication year - 2015
Publication title -
èpidemiologiâ i vakcinoprofilaktika
Language(s) - English
Resource type - Journals
eISSN - 2619-0494
pISSN - 2073-3046
DOI - 10.31631/2073-3046-2015-14-4-74-79
Subject(s) - plague (disease) , vaccination , immune system , immunity , immunology , biology , virology , medicine , pathology
The study has resulted in the comparative estimate of the immunological activity of the preparations (LPV) with optimal storage mode and after exposure to extreme temperature (37 ± 1 °С) for 6 days, followed by storage at (4 ± 2 °С). Data obtained during the study indicate an identical immune response. After-heat LPV sample did not reduce the ability to exercise immunological activity during the three-year storage (shelf-life of the drug). When the animals vaccination in this group, total number of T-lymphocytes are increased and signs of humoral immunity are shown earlier. Thus, we can predict more labile conditions on the transportation of live bacterial vaccine without compromising its characteristics.