Open AccessASSESSMENT OF THE AUTOPHAGY PROCESS IN MEN OF DIFFERENT BODY WEIGHT IN DIFFERENT AGE PERIODS
Author(s) -
I.A. Tkhakushinov
Publication year - 2021
Publication title -
nacionalʹnaâ associaciâ učënyh/nacionalʹnaâ associaciâ učenyh
Language(s) - English
Resource type - Journals
eISSN - 2782-2869
pISSN - 2413-5291
DOI - 10.31618/nas.2413-5291.2021.2.68.455
Subject(s) - autophagy , extracellular , intracellular , body water , endocrinology , medicine , zoology , lean body mass , obesity , body weight , extracellular fluid , chemistry , age groups , ageing , biology , biochemistry , demography , apoptosis , sociology
The study group consisted of 20 men of various ages (14-69 years) and weight. To assess the processes of autophagy, the activity of the protein Beclin-1 was used. In individuals with normal body weight, the presence of positive reliable correlations between the level of beclin-1 and extracellular water was revealed (r = 0.96; p <0.01). In the obese group, there was a significant positive relationship between beclin-1 and the amount of triglycerides
(r = 0,57; p <0,05); muscle mass (r = 0,62; p <0,05); lean mass (r = 0,62; p <0,05); common liquid (r = 0,62; p
<0,05). In old age, there was a direct correlation between the level of beclin-1 and intracellular fluid (r = 0,84; p <0,05). In men, autophagy was less dependent on age, and to a greater extent on the content of extracellular water in persons with normal weight and muscle mass and total water content in persons with obesity.