Open AccessSTUDY OF CHRONIC TOXICITY PARAMETERS OF A DRUG WITH HEPATOPROTECTIVE ACTIVITY
Author(s) -
Olga Vasiliadi,
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E.N. Rud,
Vladimir A. Grin,
Elena Kuzminova,
М. П. Семененко,
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Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-248-4-25-29
Subject(s) - toxicity , pharmacology , chronic toxicity , drug , body weight , physiology , medicine , toxicology , biology
Currently, the most promising and developing area in the field of veterinary pharmacology is the method of obtaining and using an innovative dosage form such as phytosomes. The article presents the results of studies to determine the chronic toxicity of a phytosomal complex with hepatoprotective activity, including silymarin, dihydroquercetin and lecithin. It was determined that its application to laboratory nonlinear rats for sixty days at doses of 150, 75 and 30 mg per animal does not have a negative effect on the organism of rats and the biochemical parameters of their blood. The preservation index in all groups was 100%. The phytosomal complex stimulates body weight gains in animals, with a difference relative to control analogs – 24.2% (group 1), 22.3% (group 2) and 8.1% (group 3). Its long-term use improves the indicators of protein and lipid metabolism, as well as the functional state of the liver within the reference values. Autopsy of laboratory animals showed no signs of intoxication. Thus, long-term use of the phytosomal complex is harmless to warm-blooded animals.