Open AccessCLINICAL TRIAL OF THE ASSOCIATED VACCINE AGAINST PARAINFLUENZA-3, INFECTIOUS RHINOTRACHEITIS, VIRAL DIARRHEA, ROTA- AND CORONAVIRUS INFECTIONS OF CATTLE INACTIVATED EMULSION
Author(s) -
Г Н Спиридонов,
Fsbsi,
V.G. Gumerov,
А Ф Махмутов,
В. В. Евстифеев,
И.Г. Каримуллина,
Biological Safety
Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-247-3-249-255
Subject(s) - virology , virus , diarrhea , coronavirus , rotavirus , vaccination , titer , medicine , biology , covid-19 , infectious disease (medical specialty) , disease
The paper presents the results of studying the efficacy of an associated emulsion vaccine against parainfluenza-3, infectious rhinotracheitis, viral diarrhea, rota- and coronavirus infections in cattle in a production environment. In the manufacture of the associated vaccine, biologically active substances were used in the form of inactivated, purified and concentrated antigens of the following virus strains: "ПТК-45/86" parainfluenza virus-3, "ТК-А (ВИЭВ)-В2" virus of infectious rhinotracheitis, "ВК-1" virus of viral diarrhea-diseases of the mucous membranes of cattle, "РМ" rotavirus and 2 "КЛ-2" coronavirus of cattle obtained in transplanted cell cultures. 8 batches of the associated vaccine were produced. A clinical trial of the effectiveness of the vaccine was carried out in 3 cattle farms of the Republic of Tatarstan, unfavorable for respiratory and intestinal infections of young cattle in terms of morbidity and safety of calves obtained from vaccinated and unvaccinated cows, as well as by titers of specific antibodies in blood serum and colostrum.