Open AccessACUTE AND CHRONIC TOXICITY OF SUCCINIC ACID AND PROBIOTICS OF KPM-2 WHEN APPLYED TOGETHER
Author(s) -
N.V. Chubynina,
Fsbei He
Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-246-2-268-271
Subject(s) - toxicity , acute toxicity , chronic toxicity , spleen , succinic acid , respiratory system , autopsy , co poisoning , biology , toxicology , medicine , biochemistry , catalysis
The article discusses issues related to the determination of acute and chronic toxicity of succinic acid and probioic KPM-2 when used together in an experiment on white mice. A study of the indicators of acute toxicity showed that the experimental mice were marked by strong excitement, convulsions, death occurred from respiratory arrest during the period of convulsions. Autopsy of the dead mice observed hyperemia of the lungs, plethora of the liver, spleen, kidneys, and asphyxiation of the heart. Yak and probiotic KPM-2, when used together, do not possess cumulative properties according to the classification of Hodge and Sterner and belong to the 4th hazard class.