Open AccessSTUDY OF THE HEPATOPROTECTIVE PROPERTIES OF HYPOXENE ON A MODEL OF EXPERIMENTAL TOXIC HEPATITIS IN WHITE RATS
Author(s) -
А. А. Резниченко
Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-245-1-160-163
Subject(s) - transamination , carbon tetrachloride , alkaline phosphatase , chemistry , toxic hepatitis , body weight , pharmacology , enzyme , hepatitis , biochemistry , medicine , endocrinology , organic chemistry
Acute toxic hepatitis was caused by intraperitoneal administration of carbon tetrachloride in vaseline oil to white rats at the rate of 0.4 ml per 100 g of body weight for 3 days once. As a result, the animals had a violation of the cytoplasmic membranes of hepatocytes, which was accompanied by an increase in serum transamination enzymes and alkaline phosphatase, a sharp decrease in glu-cose and total protein. The use of hypoxen stopped this pathological process. After using the drug, the activity of transamination enzymes and alkaline phosphatase in the blood serum of animals de-creased to physiological values, the amount of protein and glucose increased, and the physiological state of white rats improved. Thus, hypoxen can be used in animals as a hepatoprotective agent at a dose of 50.0 mg/kg of body weight.