Open AccessTHE INCIDENCE OF MASTITIS IN COWS AND THE PROPERTIES OF A NEW REMEDY FOR ITS THERAPY
Author(s) -
A.G. Norkin,
I.G. Konopeltsev,
S.V. Nikolaev,
M.B. Glukhova
Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-245-1-131-137
Subject(s) - mastitis , udder , serial dilution , staphylococcus aureus , herd , medicine , proteolytic enzymes , veterinary medicine , zoology , biology , enzyme , bacteria , pathology , biochemistry , alternative medicine , genetics
Currently, the problems of udder inflammation in cows and obtaining high-quality dairy products have not lost their relevance. With a slight increase in the breeding stock, the percentage of animals with mastitis in the herd continues to be high. A technology for producing silver nanoparti-cles (2000 ppm) has been developed. Microbiological studies have shown that native Ag solutions exhibit bactericidal properties to museum strains of E.coli and S.aureus after 24 hours, and in a 1:10 dilution after 48 hours. Dilutions of the Ag solution with glycerin had significantly lower antibacte-rial properties against E.coli and S.aureus. As part of preclinical studies, it was found that a single dose (1.0 ml) of a solution of nanosilver and a proteolytic enzyme does not cause a fatal outcome in laboratory mice. The use of the drug for two weeks caused hyperchromia and anisocytosis of red blood cells in mice, without any macroscopic changes in internal organs.