Open AccessASSESSMENT OF THE CHRONIC TOXICITY OF THE COMPOSITION OF MEDICINES TO ELIMINATE THE CONSEQUENCES OF TOXICOSIS
Author(s) -
I.I. Idiyatov,
AUTHOR_ID,
V.O. Dombrovskiy,
Y.V. Larina,
D.V. Aleev,
V.I. Egorov,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2020
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-244-4-92-97
Subject(s) - toxicity , drug , pharmacology , chronic toxicity , physiology , blood count , body weight , medicine , biology
The article presents the results of studying the chronic toxicity of a complex of therapeutic agents for eliminating the consequences of animal toxicosis, hepatoprotection and metabolic correc-tion, including choline chloride, succinic acid, xymedon, sorbitol, a suspension of lactic and propion-ic acid microorganisms. The drug was administered to white rats with food at doses of 1/50 and 1/20 of the maximum input (0.04 and 0.1 g / kg of live weight) for 60 days. Clinical, growth-weight, hematological, biochemical and pathomorphological parameters were assessed. It was found that the study drug with prolonged administration does not cause signs of toxicosis, does not have a nega-tive effect on the organism of laboratory animals. The absolute gain in live weight over the experi-ence in the experimental groups was 21.8 and 22.2 % more than the control, respectively, the drug had some growth-stimulating effect. A blood test showed that the values of the studied parameters were slightly higher than the control values, and indicated the presence of a favorable effect of the drug on hematopoiesis and metabolic processes. Macroscopic examination of internal organs showed no pathological changes.