Open AccessAnti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)
Author(s) -
Kannika Inchab,
Parirat Khonsung,
Natthakarn Chiranthanut,
Puongtip Kunanusorn,
Saranyapin Potikad,
Sunee Chansakaow,
Ampai Panthong,
Seewaboon Sireeratawong
Publication year - 2018
Publication title -
journal of health science and medical research (jhsmr)
Language(s) - English
Resource type - Journals
ISSN - 2586-9981
DOI - 10.31584/jhsmr.v36i2.1
Subject(s) - stomach , mucus , pylorus , medicine , gastroenterology , gastric acid , hydrochloric acid , stress ulcer , ethanol , chemistry , pharmacology , biochemistry , biology , inorganic chemistry , ecology
Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum) water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.