Open AccessNanotoxicity of corona-nanoparticles (SARS-COV-2): Nano mechanisms of hypoxia
Author(s) -
Amel Hanini
Publication year - 2020
Publication title -
clinical medical reviews and reports
Language(s) - English
Resource type - Journals
ISSN - 2690-8794
DOI - 10.31579/2690-8794/031
Subject(s) - nanotoxicology , virus , hypoxia (environmental) , covid-19 , ebola virus , acute respiratory distress , coronavirus , virology , nanoparticle , medicine , chemistry , immunology , infectious disease (medical specialty) , nanotechnology , oxygen , disease , materials science , pathology , lung , organic chemistry
The present review aim to help scientific community to better understand, in vitro and in vivo, COVID-19 compared to Monge disease (MD). The SARS-COV-2 or Corona-nanoparticles (NPs: 60-140nm) model based on nanosciences give an innovative understanding of virus nanotoxicity associated to violent inflammatory reactions and acute respiratory distress. Our analysis of COVID-19 suggest for the first time as far as we know that SARS-COV-2 use nanosciences laws such as virus agglomeration and mitochondria respiration toxicity induced by cluster virus-Heme. Moreover, the implication of age, gender, and ethnicity to COVID-19 must be confirmed by future studies compared to MD. Virus could use nanomechanisms to induce hypoxia via generation of Heme-virus clusters mitigating microcoagulation implicated in acute respiratory distress and heart failure. Our analysis point to the presence of possible link between hypoxia and COVID-19 pro-pulmonary complications.