Review Article: Improving Clinical Utility with Molecular Profiling – A Review of Critical Success Factors

Molecular profiling is becoming a new standard to optimize treatment for patients with locally advanced or metastatic solid tumors. Different approaches are currently being adopted for molecular profiling and in a recent review we found substantial differences in the reported clinical outcomes [1]. Here we explain the complex processes required to generate a molecular profile, which will lead to improved treatment outcomes and find reasons for the considerable differences in the clinical outcomes observed between the various approaches to molecular profiling.