Open AccessShort Communication:The Effects Chronic Acetaminophen Treatment on Age-Associated Alterations of Cardiac Function in the Female F344xBN Heart
Author(s) -
Kevin M. Rice
Publication year - 2018
Publication title -
clinical cardiology and cardiovascular interventions
Language(s) - English
Resource type - Journals
ISSN - 2641-0419
DOI - 10.31579/2641-0419/010
Subject(s) - medicine , ventricle , oxidative stress , diastole , acetaminophen , cardiology , cardiac function curve , isovolumic relaxation time , endocrinology , physiology , diastolic function , anesthesia , heart failure , blood pressure
Background Although several studies have investigated the age-associated changes in male and female F344 as well as male Fischer 344/NNiaHSD x Brown Norway/BiNia F1 (F344xBN), no study to our knowledge has examined the age-associated changes in structure and function in the female F344xBN heart using echocardiographic measures. This information is crucial in determining whether or not the female F344xBN is an appropriate aging model. Additional studies have also suggested that age-associated increases in levels of oxidative stress may cause cardiac dysfunction and that chronic acetaminophen (APAP) ingestion may be protective against increased oxidative stress. On the basis of these studies we examined the function and structure of the aged female F344xBN heart in the absence and presence of chronic APAP treatment. Methods To investigate if the aging-related changes in cardiovascular structure and function can be attenuated with APAP treatment, aged (22-month old) female F344xBN rats were administered APAP (30 mg/kg body weight/day) for 8 months in drinking water and echocardiograms assessments were performed. Results Aging was associated with evidence of diastolic (impaired left ventricle relaxation time) and systolic dysfunction (fractional shortening and end systolic volume). The incidence of arrhythmias was not different with age. However, valvular dysfunction was increased. Chronic APAP treatment did not attenuate the age-associated changes in cardiac structure and function in the female F344xBN. However the occurrence of valve dysfunction with aging was significantly lowered in the APAP treated 30-month female hearts.