Thyroxine Supplementation May Improve Ovulation and Pregnancy Rates in Infertile Patients with Polycystic Ovary Syndrome and Subclinical Hypothyroidism | Zendy

Hesham Ammar | Zendy

Open Access

Thyroxine Supplementation May Improve Ovulation and Pregnancy Rates in Infertile Patients with Polycystic Ovary Syndrome and Subclinical Hypothyroidism

Author(s) -

Hesham Ammar

Publication year - 2019

Publication title -

obstetrics gynecology and reproductive sciences

Language(s) - English

Resource type - Journals

ISSN - 2578-8965

DOI - 10.31579/2578-8965/019

Subject(s) - polycystic ovary , ovulation , ovulation induction , medicine , subclinical infection , pregnancy , pregnancy rate , infertility , gynecology , endocrinology , induced ovulation , clomifene , hormone , insulin resistance , biology , insulin , genetics

This prospective observational study was conducted on 220 patients with polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) who were allocated into two groups; group one (n=112) received clomiphene citrate (CC) plus thyroxine while group two received only CC for ovulation induction. Patients receiving CC and thyroxine exhibited higher ovulation rate (p<0.001), higher endometrial thickness (p<0.05), higher number of dominant follicles (p<0.001) and higher pregnancy rate (p<0.001) compared to their counterparts receiving only CC. Thyroxine supplementation improves ovulation and pregnancy rates in infertile patients with PCOS and SCH receiving CC for ovulation induction who are therapy naïve.

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