Open AccessThyroxine Supplementation May Improve Ovulation and Pregnancy Rates in Infertile Patients with Polycystic Ovary Syndrome and Subclinical Hypothyroidism
Author(s) -
Hesham Ammar
Publication year - 2019
Publication title -
journal of obstetrics gynecology and reproductive sciences
Language(s) - English
Resource type - Journals
ISSN - 2578-8965
DOI - 10.31579/2578-8965/019
Subject(s) - polycystic ovary , ovulation , ovulation induction , medicine , subclinical infection , pregnancy , pregnancy rate , infertility , gynecology , endocrinology , induced ovulation , clomifene , hormone , insulin resistance , biology , insulin , genetics
This prospective observational study was conducted on 220 patients with polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) who were allocated into two groups; group one (n=112) received clomiphene citrate (CC) plus thyroxine while group two received only CC for ovulation induction. Patients receiving CC and thyroxine exhibited higher ovulation rate (p<0.001), higher endometrial thickness (p<0.05), higher number of dominant follicles (p<0.001) and higher pregnancy rate (p<0.001) compared to their counterparts receiving only CC. Thyroxine supplementation improves ovulation and pregnancy rates in infertile patients with PCOS and SCH receiving CC for ovulation induction who are therapy naïve.