Open AccessMajor Critical Periods in Developmental Pathogenomics of Endometriosis
Author(s) -
Vladislav Baranov
Publication year - 2019
Publication title -
journal of obstetrics gynecology and reproductive sciences
Language(s) - English
Resource type - Journals
ISSN - 2578-8965
DOI - 10.31579/2578-8965/017
Subject(s) - endometriosis , reprogramming , biology , endometrium , uterus , bioinformatics , evolutionary biology , genetics , gynecology , medicine , gene , endocrinology
In spite on numerous experimental and clinical data molecular mechanisms of endometriosis (EM) - the most common benign tumor of the female reproductive tract still remains obscure . The deciphering enigmas of EM gave a birth to a number of hypothesis . System genetics approach used in our studies of common diseases support the existence of special genetic program of EM operative in its development. It is taken for granted that EM results from abnormal differentiation of stem cells (SC). Two major sources of EM SC are considered : SC disseminated throughout peritoneumduring female reproductive organs embryogenesis , SC from junction zone the uterine endometrium (2) [6]. According to our reviewed hypothesis [7] the genetic program of EM consists of several critical periods (CP) [8] corresponding to three crucial events in EM development with each of them corresponding to major genome reprogramming in EM cells.