Open AccessCharacteristics and Prognostic Factors in Gastric Adenocarcinoma Patients with Distant Metastasis
Author(s) -
Tien Manh Hoang,
Van Hieu Hoang,
Thi Thu Hoai Bui
Publication year - 2022
Publication title -
asian pacific journal of cancer biology
Language(s) - English
Resource type - Journals
ISSN - 2538-4635
DOI - 10.31557/apjcb.2021.6.4.255-261
Subject(s) - medicine , multivariate analysis , brain metastasis , oncology , proportional hazards model , metastasis , stage (stratigraphy) , adenocarcinoma , univariate analysis , survival analysis , bone metastasis , cancer , gastric adenocarcinoma , lung cancer , log rank test , paleontology , biology
Objective: To explore the characteristics and prognostic factors of distant metastatic gastric adenocarcinoma (DMGA). Methods: The data of DMGA patients who were enrolled in the SEER database from 2010 to 2017 was obtained. The Chi-squared test was performed for comparison between groups. The Kaplan-Meier method and the log-rank test was used for survival analysis. Univariate and multivariate Cox regression analysis was used to identify independent prognostic factors. Results: A total of 2324 DMGA patients was identified. The association between different metastatic sites and clinicopathological characteristics was detected. The survival curves of patients with single and double-organ metastasis were established. The multivariate Cox analysis indicated that age, histological grade, T stage, N stage, surgery and tumor size were independent prognostic factors. Conclusion: DMGA patients have poor outcomes, especially brain metastasis, bone metastasis, liver-brain metastasis, and lung-brain metastasis. Age <60 years old and cancer-directed surgery indicated a better prognosis, while higher T and N stage, higher grade and tumor size ≥5 cm indicated a worse prognosis.