Open AccessMDM2 (T309G) Gene Polymorphism Determines the Susceptibility of Hepatocellular Carcinoma in Bangladesh
Author(s) -
Md. Bayejid Hosen,
Narwana Khaleque,
Sajib Chakraborty,
Mamun Al Mahtab,
Yearul Kabir
Publication year - 2021
Publication title -
asian pacific journal of cancer biology
Language(s) - English
Resource type - Journals
ISSN - 2538-4635
DOI - 10.31557/apjcb.2021.6.3.213-217
Subject(s) - hepatocellular carcinoma , genotyping , genotype , medicine , allele , mdm2 , oncology , population , gastroenterology , biology , gene , genetics , environmental health
Background: Hepatocellular carcinoma (HCC) is one of the fatal cancer types worldwide, and a variety of genetic factors are considered to be associated with this incidence. MDM2 gene plays a pivotal role in various pathways, which are essential to combat tumor formation. The study aimed to find out the associations of MDM2 (T309G, rs2279744) gene polymorphism with the development of HCC in the Bangladeshi population. Methods: A case-control study on 100 HCC patients and 110 control subjects was conducted. The genotyping of the MDM2 (T309G) gene was done using PCR-RFLP methods. Results: The percentage of TT and GG genotypes were significantly different (p 0.05). In addition, patients having either GG or TG genotypes showed higher risk for HCC compared to control group (OR = 2.20; 95% CI = 1.21–4.14; P < 0.05). Conclusion: Our study suggested that the MDM2 gene may have a strong association with the development of HCC, and the GG allele could serve as an essential determinant to identify the higher risk of HCC in the Bangladeshi population.