Open AccessAberrant expression and methylation of individual microRNAs genes in lymphoproliferative diseases: a literature review
Author(s) -
Е. Н. Воропаева,
AUTHOR_ID,
О. В. Березина,
М. И. Чуркина,
Т И Поспелова,
A.A. Lyzlova,
В. Н. Максимов,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2021
Publication title -
journal of siberian medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2542-1174
DOI - 10.31549/2542-1174-2021-4-108-133
Subject(s) - microrna , methylation , biology , epigenetics , gene , dna methylation , lymphoproliferative disorders , haematopoiesis , gene expression , function (biology) , cancer research , clinical significance , genetics , immunology , pathology , lymphoma , medicine , stem cell
In recent decades, it has been found that microRNAs are involved in almost all cellular processes, including the development of tumors. In this paper, we consider the molecular genetic characteristics of a number of microRNAs that function in normal hematopoiesis, whose expression is impaired in the development of lymphoproliferative diseases. The last published results of studies on the diagnostic, prognostic and clinical significance of gene methylation considered by microRNAs in malignant neoplasms of the blood system are presented.