Open AccessDevelopment of the voltammetric method for the quantitative determination of bendazole hydrochloride
Author(s) -
E.Yu. Zherebtsova,
S.V. Terentyeva,
E. A. Ivanovskaya,
Takeshi Shinko
Publication year - 2021
Publication title -
journal of siberian medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2542-1174
DOI - 10.31549/2542-1174-2021-1-55-64
Subject(s) - hydrochloride , detection limit , electrolysis , chromatography , chemistry , pharmaceutical formulation , electrode , organic chemistry , electrolyte
In connection with the wide field of application of bendazole hydrochloride in medicine and its use as a part of combined drugs, an assessment of the effectiveness of the novel dosage forms and the determination of pharmacokinetic parameters are required. For this purpose, it is necessary to obtain data on the concentration of the studied drug in biological fluids. The aim of this research is to develop a voltammetric method for the bendazole hydrochloride quantification. In the course of the study, the optimal electrolysis conditions were established: potential was –1.8 V, time 15 s, and potential sweep rate 50 mV/s. The opti-mum pH value for electrolysis of bendazole hydrochloride is 6–7. The proposed method is validated by tests: specificity and linearity, detection limit; the range of the procedure and its analytical precision were determined. Thus, the developed method can be used for the quantification of bendazole hydrochloride in pharmaceutical substances.