Formulation and Evaluation of Combined Dosage Form of Diclofenac Sodium (Mini Tablet) and Omeprazole Sodium in Capsule Devices

The work investigates the formulation and evaluation of combined dosage form of diclofenac sodium (mini tablet) and omeprazole sodium in capsule devices. The design of effective and safe drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deliver drugs over a long period of time or for a well-controlled release profile, to minimizing the loss of drug, to reduce the side effect. The continuous release mini matrix tablet of diclofenac sodium prepared by wet granulation using HPMC, the patients at risk for ulcer disease who require treatment for arthritis receive nonsteroidal anti-inflammatory drugs (NSAIDs) that are selective for cyclooxygenase-2 or the combination of a nonselective NSAID with a proton-pump inhibitor. We assessed whether celecoxib would be similar to diclofenac plus omeprazole in reducing the risk of recurrent ulcer bleeding in patients at high risk for bleeding.