Open AccessA PRELIMINARY STUDY OF THE EFFECT OF ANESTHETIC AGENTS ON THE RHEOLOGICAL PARAMETERS OF GLYCATED ERYTHROCYTES
Author(s) -
M. V. Batista da Silva,
Horacio Castellini,
N. A. Alet,
Bibiana Riquelme,
Analía I. Alet
Publication year - 2021
Publication title -
anales/anales afa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 2
eISSN - 1850-1168
pISSN - 0327-358X
DOI - 10.31527/analesafa.2020.31.4.117
Subject(s) - glycation , rheology , hemorheology , remifentanil , microcirculation , anesthetic , chemistry , erythrocyte deformability , rheometer , erythrocyte aggregation , erythrocyte membrane , pharmacology , biophysics , diabetes mellitus , medicine , anesthesia , propofol , materials science , red blood cell , biochemistry , membrane , fibrinogen , endocrinology , composite material , biology
This paper presents a preliminary study of the effects of the anesthetics propofol, remifentanil, and vecuronium bromide on the rheological properties of glycated erythrocytes in vitro, modeling the glycation by hyperglycemia observed in diabetes. Viscoelastic and aggregation kinetic parameters of erythrocytes were determined using an erythrocyte rheometer and an optical chip aggregometer developed in our laboratory. The results showed significant alterations in the membrane surface viscosity, the elastic modulus, and the erythrocyte deformability index for the different anesthetics studied. Also, the kinetics aggregation parameters showed different types of alterations due to the effect of anesthetics. This preliminary study suggests that the use of these anesthetics in diabetic patients could induce hemorheological alterations that disturb the microcirculation. For this reason, it is recommended to deepen these investigations to prevent complications in surgical procedures.