Open AccessHarnessing the heterogeneity of aging
Author(s) -
Warren Ladiges
Publication year - 2021
Publication title -
aging pathobiology and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2690-1803
DOI - 10.31491/apt.2021.03.048
Subject(s) - epigenetics , divergence (linguistics) , homogeneous , gene , biology , histone , evolutionary biology , population , genetics , function (biology) , medicine , linguistics , philosophy , physics , environmental health , thermodynamics
Genetic variation does not entirely address the consistent divergence of healthy and unhealthy aging in heterogeneous and homogeneous mammalian populations. The alteration of gene function through modification of histone DNA infrastructure is a logical extending explanation for this divergence. Since epigenetic alterations are reversible, therapeutic interventions that target the right gene or gene products could reverse aging, at the very least in the population of older people with poor health. Keywords: Heterogeneity of aging, epigenetic alterations, reversing aging