Open AccessBiologically active derivatives of fullerene C60. Current state and development prospects
Author(s) -
С. Д. Фазылов,
A.Zh. Issayeva,
Z. M. Muldakhmetov,
А. М. Газалиев,
А. Е. Аринова,
M. K. Ibraev,
L.M. Vlasova,
A. S. Fazylov
Publication year - 2020
Publication title -
ķaraġandy universitetìnìn̦ habaršysy. himiâ seriâsy
Language(s) - English
Resource type - Journals
eISSN - 2663-4872
pISSN - 2518-718X
DOI - 10.31489/2020ch3/11-20
Subject(s) - fullerene , chemistry , combinatorial chemistry , biological activity , solubility , organic chemistry , in vitro , biochemistry
The article presents literature review on the physicochemical and biological properties of fullerene C60, as well as the authors' own experimental data on the synthesis of fullerene derivatives of amines and natural alkaloids. It is shown that the presence of a fullerene fragment in the structure of the compound provides a significant improvement or the appearance of qualitatively new mechanical, chemical, physical, biological and other properties associated with the manifestation of nanoscale factors. The issues of the relationship of the structure, water solubility and biological activity of fullerene С60 derivatives are considered. Many biologically active effects of various modified derivatives of fullerene C60 are described, which have membrane-active, antibacterial, antiviral, immunomodulating, HIV inhibitory enzymes and other properties. It was noted that preparations containing a fullerene fragment are effective against hepatitis C virus, and are also able to efficiently trap free radicals. Derivatives of fullerenes can also be used as antioxidant, neuroprotective and other agents. Particular attention is paid to the authors' own results on the synthesis of amino derivatives of fullerenes.