Open AccessTransferring Mesenchymal Stem Cells to the Osteoarthritic Cartilage: Translating Science to Medicine
Author(s) -
J Agilinko,
J Agilinko,
A Yoong,
Bertrand Agilinko,
Mohammad Hasan,
Daniele Fanelli
Publication year - 2020
Publication title -
surgical case reports
Language(s) - English
Resource type - Journals
ISSN - 2613-5965
DOI - 10.31487/j.scr.2020.10.04
Subject(s) - mesenchymal stem cell , chondrogenesis , osteoarthritis , cartilage , regenerative medicine , medicine , stem cell , bioinformatics , pathology , biology , anatomy , microbiology and biotechnology , alternative medicine
Osteoarthritis (OA) is associated with loss of the phenotypic stability of affected joints. Due to its avascularnature, biomechanical properties of the cartilage tissue in a synovial joint are particularly compromised asthe disease progresses. Current therapies for OA merely buy time until arthrodesis or arthroplasty, the ‘endgame’, is ultimately reached. Over the last two decades, promising experimental data has started to emergeon mesenchymal stem cells (MSCs) as candidate cell types for cell and/ or tissue-based cartilage tissuerepair. The principal attraction of MSCs lies in their consistent chondrogenic differentiation andproliferative propensities. Practically, they offer ease of isolation and culture-expansion. Targeted genetherapy can further enhance their delivery into osteoarthritic joints. Henceforth, understanding the biologicalactivities and mechanisms of action of MSCs is crucial for a rational approach to their clinical applicationin osteoarthritic joints.