Open AccessChronic inflammation and progression of chronic kidney disease in patients with type 2 diabetes
Author(s) -
T. S. Mazur,
Nadiia Demikhova,
T. M. Rudenko,
Alla Vladyslavivna Yurchenko,
Olha Yezhova,
Світлана Іванівна Бокова,
A. Demikhov
Publication year - 2021
Publication title -
ukraïnsʹkij žurnal nefrologìï ta dìalìzu
Language(s) - English
Resource type - Journals
eISSN - 2616-7352
pISSN - 2304-0238
DOI - 10.31450/ukrjnd.4(72).2021.05
Subject(s) - albuminuria , medicine , kidney disease , inflammation , type 2 diabetes , diabetes mellitus , proinflammatory cytokine , type 2 diabetes mellitus , endocrinology , gastroenterology
Chronic inflammation, atherosclerosis, tubulointerstitial fibrosis, and vascular damage play a crucial role in the progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (DM). However, specific biomarkers that can determine the progression of diabetic kidney disease, including patients with minimal albuminuria, remain undefined.
The present study aimed to determine markers of chronic inflammation as indicators of CKD progression in patients with type 2 DM.
Methods. 45 patients with type 2 DM and stage 1-3 CKD were involved in this cross-sectional observational study. Analysis of cellular mechanisms of CKD progression was performed on the concentrations of endothelin-1 (ET-1), fibronectin (FN), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), and monocyte chemoattractant protein (MCP) -1) in the serum.
Results. In patients with type 2 DM, an increasing trend in the majority of endothelial and proinflammatory mediators was found according to the CKD stages despite normal albuminuria.
Conclusions. Concentrations of TNF-α, ET, TGF-β1 and MCP-1 can be used to assess the progression of CKD in patients with type 2 DM with normal albuminuria. Further researches are needed to determine early indicators of diabetic kidney disease progression.