Open AccessSECRETORY IMMUNOGLOBULIN A LEVEL IN SALIVA OF CHRONIC KIDNEY DISEASE PATIENTS ON DIALYSIS
Author(s) -
Анастасия Васильевна Климчук
Publication year - 2014
Publication title -
ukraïnsʹkij žurnal nefrologìï ta dìalìzu
Language(s) - English
Resource type - Journals
eISSN - 2616-7352
pISSN - 2304-0238
DOI - 10.31450/ukrjnd.1(41).2014.03
Subject(s) - immunology , antibody , saliva , inflammation , immune system , immunoglobulin a , dialysis , secretory iga , bacterial translocation , medicine , chromosomal translocation , immunoglobulin g , microbiology and biotechnology , biology , biochemistry , gene
Dialysis patients have elevated levels of markers of inflammation. Endotoxin of gram negative bacteria is one of the most potent inducers of inflammation. Endotoxin translocation from the gut into the blood can triggerproinflammatory response. Secretory immunoglobulin A (sIgA) in the mucous membranes can neutralize bacterial toxins and prevent their translocation, if the immune response is adequate.