Open AccessSynthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel
Author(s) -
Jiaxiu Guo,
L. Li,
Yang Ti,
J. Yhu
Publication year - 2007
Publication title -
express polymer letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.695
H-Index - 72
ISSN - 1788-618X
DOI - 10.3144/expresspolymlett.2007.26
Subject(s) - materials science , sulfadiazine , 2 pyrrolidone , self healing hydrogels , chemical engineering , polymer chemistry , chemistry , biochemistry , antibiotics , engineering
Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction temperature, reaction time, the monomer ratio, and the amount of the cross-linker on the pH sensitivity of the hydrogel were investigated. Results indicate that the hydrogel shows strong pH sensitivity in the pH range of 6.5 to 7.2. It also exhibits a good swelling reversibility at buffer solutions of pH 6.5 and 7.2. At last, drugs tests demonstrated the release effect of the hydrogel in pH range of 6.5 to 7.2