Open AccessCytomegalovirus (CMV) Infection in Infants: Two Case Reports and Review of Literature
Author(s) -
Zeti Norfidiyati Salmuna,
Norjihan Abdul Hamid,
Alwi Muhd Besari,
Mohd Zulfakar Mazlan,
Suharni Mohamad
Publication year - 2021
Publication title -
international medical journal malaysia/iium medical journal malaysia
Language(s) - English
Resource type - Journals
eISSN - 2735-2285
pISSN - 1823-4631
DOI - 10.31436/imjm.v20i3.1523
Subject(s) - medicine , cytomegalovirus , ganciclovir , jaundice , pediatrics , small for gestational age , gestational age , herpesviridae , immunology , surgery , pregnancy , human cytomegalovirus , virus , viral disease , biology , genetics
Cytomegalovirus (CMV) is a virus under the Herpesviridae family. We describe two case reports on different manifestations of infants with CMV infection presented with neonatal jaundice, small for gestational age (SGA) and congenital cataract. Congenital CMV (cCMV) was diagnosed in a neonate presented with jaundice and SGA. cCMV cannot be excluded in another case as no CMV PCR done within 3 weeks of life. Only one cCMV infection was treated with 6 weeks of ganciclovir anti-viral therapy, which presented with neonatal jaundice, SGA with a very high CMV viral load. All cases were under multidisciplinary follow[1]up, including pediatric for developmental assessments, audiologist for hearing assessment, and ophthalmology for vision assessment. These case reports describe the importance of thorough clinical examination and early screening of CMV infection in infants to rule out cCMV as CMV is the commonest congenital treatable viral infection in Malaysia. Early treatment and intervention can be planned for child wellbeing.