Open AccessPreliminary Study on the Formulation of Syariah Compliant Generic Sustained Release Gliclazide Tablet Using Xanthan Gum
Author(s) -
Nik Mohamad Lukman Mat Zin,
Anis Syazwani Abd Mubin,
Mohamed Sufian Mohd. Nawi,
Abul Bashar Mohammed Helaluddin,
Abdul Razak Kasmuri,
Uttam Kumar Mandal
Publication year - 2018
Publication title -
international medical journal malaysia/iium medical journal malaysia
Language(s) - English
Resource type - Journals
eISSN - 2735-2285
pISSN - 1823-4631
DOI - 10.31436/imjm.v17i2.982
Subject(s) - gliclazide , medicine , granulation , tableting , xanthan gum , bioavailability , immediate release , sulfonylurea , dosage form , pharmaceutics , pharmacology , repaglinide , glipizide , diabetes mellitus , traditional medicine , insulin , type 2 diabetes , chromatography , chemistry , physics , materials science , classical mechanics , rheology , composite material , endocrinology
Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that the outcome of our study will result in a suitable formulation that could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month.