Open AccessНОВЫЕ ПАТОГЕНЕТИЧЕСКИЕ ФАКТОРЫ АНДРОГЕНЗАВИСИМЫХ ДЕРМАТОПАТИЙ
Author(s) -
F. V. Azimova,
М Б Ходжаева
Publication year - 2019
Publication title -
web of scholar/web of scholar
Language(s) - English
Resource type - Journals
eISSN - 2518-1688
pISSN - 2518-167X
DOI - 10.31435/rsglobal_wos/31072019/6601
Subject(s) - acne , androgen receptor , endocrinology , pathogenesis , medicine , androgen , cytochrome , receptor , biology , chemistry , enzyme , biochemistry , genetics , prostate cancer , cancer , hormone
This article is devoted to the study of coregulators of androgen receptor activity in the pathogenesis of androgen-dependent dermatopathies, in particular, for acne - 25-OH-VD, cytochrome p 450 (17-alpha hydroxylase), insulin-like growth factor. There were 46 patients with acne from 14 to 25 years of age under observation. The results of studies showed significant violations of the enzymes regulating androgen receptors - 25-OH-VD, cytochrome p 450 (17-alpha hydroxylase), as well as the growth factor (insulin-like growth factor), which are important in the pathogenesis of fast non-genomic molecular cell reactions of peripheral androgens metabolism with acne.